Research workbench
Haddock calculated model of the complex between the brct region of rfc P140 and dsdna
Analyse Haddock calculated model of the complex between the brct region of rfc P140 and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2K7F
- Type
- protein + DNA
- Length
- 133 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Replication factor C subunit 1; 5'-D(P*DCP*DGP*DAP*DCP*DCP*DTP*DCP*DGP*DAP*DGP*DAP*DTP*DCP…
- UniProt
- P35251
- Pockets
- 2 · best druggability 0.65
Structure
solution nmr · 3 distinct chains · 33% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Replication factor C subunit 1 | protein | 109 | 33% helix, 12% strand | P35251 |
| B | 5'-D(P*DCP*DGP*DAP*DCP*DCP*DTP*DCP*DGP*DAP*DGP*DAP*DTP*DCP* da)-3' | dna | 14 | — | — |
| C | 5'-D(P*DCP*DTP*DCP*DGP*DAP*DGP*DGP*DTP*DCP*DG)-3' | dna | 10 | — | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 249 | 0.65 | 0.83 | 30 | empty |
| 2 | 55 | 0.31 | 0.77 | 12 | empty |
Interfaces
3 interfaces between chains.
- A–B · 645 Ų buried · 13 hydrogen bonds · protein-nucleic
- B–C · 591 Ų buried · 57 hydrogen bonds · nucleic-nucleic
- A–C · 397 Ų buried · 17 hydrogen bonds · protein-nucleic
Compared structures
- 2K7F · HADDOCK calculated model of the complex between the BRCT region of RFC p140 and dsDNA · the same entry in another collection · chain A against A, TM-score 1.00
- P35251 · AlphaFold monomer V2.0 prediction for replication factor C subunit 1 (P35251) · a predicted model of the same protein · chain A against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35251
- Elsewhere: RCSB PDB 2K7F · PDBe 2K7F · UniProt P35251
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.