MolNFT v1 · #42024 · protein

Solution structure of myirstoylated yeast ARF1 protein, GDP-bound

2K5U · ADP-ribosylation factor 1: “Solution structure of myirstoylated yeast ARF1 protein, GDP-bound”. Solution nmr, 2 ligands (MYR, GDP), 2 pockets (best druggability 0.72). MolNFT v1 #42024 on GenesisL1: 3D structure, binding sites and…

PDB: 2K5U
Type: protein
Length: 180 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ADP-ribosylation factor 1
UniProt: P11076
Ligands: MYR, GDP
Pockets: 2 · best druggability 0.72

Structure

solution nmr · 1 distinct chain · 32% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ADP-ribosylation factor 1	protein	180	32% helix, 22% strand	P11076

Ligands and binding sites

MYR · Myristic acid · ligand · chains A
GDP · Guanosine-5'-diphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	677	0.72	0.78	61	MYR
2	118	0.60	0.85	24	empty

Modifications

Observed in the structure: 1 lipid (myristoylation).

Compared structures

2K5U · Solution structure of myirstoylated yeast ARF1 protein, GDP-bound · the same entry in another collection · chain A against A, TM-score 1.00
P11076 · AlphaFold monomer V2.0 prediction for ADP-ribosylation factor 1 (P11076) · a predicted model of the same protein · chain A against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11076
Elsewhere: RCSB PDB 2K5U · PDBe 2K5U · UniProt P11076

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.