MolNFT v1 · #41755 · protein

Structure of the EPS15-EH2 STONIN2 complex

2JXC · Epidermal growth factor receptor substrate 15: “Structure of the EPS15-EH2 STONIN2 complex”. Solution nmr, 1 ligand (CA). MolNFT v1 #41755 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2JXC
Type: protein
Length: 135 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Epidermal growth factor receptor substrate 15; Stonin-2
UniProt: P42566, Q8WXE9
Ligands: CA

Structure

solution nmr · 2 distinct chains · 40% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Epidermal growth factor receptor substrate 15	protein	95	53% helix, 7% strand	P42566
B	Stonin-2	protein	40	10% helix, 0% strand	Q8WXE9

Ligands and binding sites

CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 1137 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

2JXC · Structure of the EPS15-EH2 Stonin2 Complex · the same entry in another collection · chain A against A, TM-score 1.00
P42566 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor substrate 15… · a predicted model of the same protein · chain A against A, TM-score 0.93
Q8WXE9 · AlphaFold monomer V2.0 prediction for stonin-2 (Q8WXE9) · a predicted model of the same protein · chain B against A, TM-score 0.30

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42566
Every structure of UniProt Q8WXE9
Elsewhere: RCSB PDB 2JXC · PDBe 2JXC · UniProt P42566 · UniProt Q8WXE9

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