MolNFT v1 · #41641 · protein
NMR solution structure of a LDB1-LID:LHX3-lim complex
2JTN · Lim domain-binding protein 1, LIM/HOMEOBOX protein LHX3: “NMR solution structure of a LDB1-LID:LHX3-lim complex”. Solution nmr, 1 ligand (ZN), 2 pockets (best druggability 0.31). MolNFT v1 #41641 on GenesisL1: 3D structure, binding…
- PDB
- 2JTN
- Type
- protein
- Length
- 182 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lim domain-binding protein 1, LIM/HOMEOBOX protein LHX3
- UniProt
- P70662, P50481
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.31
Structure
solution nmr · 1 distinct chain · 7% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lim domain-binding protein 1, LIM/HOMEOBOX protein LHX3 | protein | 182 | 7% helix, 18% strand | P70662, P50481 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.31 | 0.75 | 18 | empty |
| 2 | 66 | 0.30 | 0.74 | 16 | empty |
Compared structures
- 2JTN · NMR Solution Structure of a ldb1-LID:Lhx3-LIM complex · the same entry in another collection · chain A against A, TM-score 1.00
- P50481 · AlphaFold monomer V2.0 prediction for LIM/HOMEOBOX protein LHX3 (P50481) · a predicted model of the same protein · chain A against A, TM-score 0.61
- P70662 · AlphaFold monomer V2.0 prediction for lim domain-binding protein 1 (P70662) · a predicted model of the same protein · chain A against A, TM-score 0.28
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P70662
- Every structure of UniProt P50481
- Elsewhere: RCSB PDB 2JTN · PDBe 2JTN · UniProt P70662 · UniProt P50481
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