MolNFT v1 · #41621 · protein

Solution structure of F104W cardiac troponin C

2JT0 · Troponin C, slow skeletal and cardiac muscles: “Solution structure of F104W cardiac troponin C”. Solution nmr, 3 pockets (best druggability 0.63). MolNFT v1 #41621 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2JT0
Type: protein
Length: 161 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Troponin C, slow skeletal and cardiac muscles
UniProt: P63316
Pockets: 3 · best druggability 0.63

Structure

solution nmr · 1 distinct chain · 58% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Troponin C, slow skeletal and cardiac muscles	protein	161	58% helix, 4% strand	P63316

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	201	0.63	0.83	25	empty
2	98	0.62	0.87	18	empty
3	71	0.35	0.76	19	empty

Compared structures

2JT0 · Solution structure of F104W cardiac troponin C · the same entry in another collection · chain A against A, TM-score 1.00
P63316 · AlphaFold monomer V2.0 prediction for troponin C, slow skeletal and cardiac muscles… · a predicted model of the same protein · chain A against A, TM-score 0.47

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63316
Elsewhere: RCSB PDB 2JT0 · PDBe 2JT0 · UniProt P63316

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