MolNFT v1 · #41510 · protein + RNA

Structural basis of RSMA/CSRA RNA recognition: structure of rsme bound to the shine-dalgarno sequence of hcna mRNA

2JPP · RNA (5'- R(*GP*GP*GP*CP*UP*UP*CP*AP*CP*GP*GP*AP*UP*GP*AP*AP*…: “Structural basis of RSMA/CSRA RNA recognition: structure of rsme bound to the shine-dalgarno sequence of hcna…”. Solution nmr, 3 pockets (best druggability 0.43).…

PDB: 2JPP
Type: protein + RNA
Length: 146 residues
Chains: 4
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA (5'- R(*GP*GP*GP*CP*UP*UP*CP*AP*CP*GP*GP*AP*UP*GP*AP*AP*GP*CP*CP*C)-3')…
UniProt: Q5MXB2
Pockets: 3 · best druggability 0.43

Structure

solution nmr · 2 distinct chains · 13% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C, D	RNA (5'- R(GPGPGPCPUPUPCPAPCPGPGPAPUPGPAPAPGPCPCPC)-3')	rna	20	—	—
A, B	Translational repressor	protein	53	13% helix, 55% strand	Q5MXB2

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	181	0.43	0.74	22	empty
2	156	0.40	0.73	18	empty
3	50	0.28	0.76	13	empty

Interfaces

6 interfaces between chains.

A–B · 1950 Å² buried · 39 hydrogen bonds · protein-protein
C–B · 747 Å² buried · 21 hydrogen bonds · protein-nucleic
D–A · 726 Å² buried · 23 hydrogen bonds · protein-nucleic
D–B · 445 Å² buried · 11 hydrogen bonds · protein-nucleic
C–A · 414 Å² buried · 8 hydrogen bonds · protein-nucleic

Compared structures

2JPP · Structural basis of RsmA/CsrA RNA recognition: Structure of RsmE bound to the… · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5MXB2
Elsewhere: RCSB PDB 2JPP · PDBe 2JPP · UniProt Q5MXB2

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