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Structural basis of RSMA/CSRA RNA recognition: structure of rsme bound to the shine-dalgarno sequence of hcna mRNA

Analyse Structural basis of RSMA/CSRA RNA recognition: structure of rsme bound to the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2JPP
Type
protein + RNA
Length
146 residues
Chains
4
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
RNA (5'- R(*GP*GP*GP*CP*UP*UP*CP*AP*CP*GP*GP*AP*UP*GP*AP*AP*GP*CP*CP*C)-3')…
UniProt
Q5MXB2
Pockets
3 · best druggability 0.43

Structure

solution nmr · 2 distinct chains · 13% helix, 55% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
C, DRNA (5'- R(*GP*GP*GP*CP*UP*UP*CP*AP*CP*GP*GP*AP*UP*GP*AP*AP*GP*CP*CP*C)-3')rna20——
A, BTranslational repressorprotein5313% helix, 55% strandQ5MXB2

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11810.430.7422empty
21560.400.7318empty
3500.280.7613empty

Interfaces

6 interfaces between chains.

  • A–B · 1950 Ų buried · 39 hydrogen bonds · protein-protein
  • C–B · 747 Ų buried · 21 hydrogen bonds · protein-nucleic
  • D–A · 726 Ų buried · 23 hydrogen bonds · protein-nucleic
  • D–B · 445 Ų buried · 11 hydrogen bonds · protein-nucleic
  • C–A · 414 Ų buried · 8 hydrogen bonds · protein-nucleic

Compared structures

  • 2JPP · Structural basis of RsmA/CsrA RNA recognition: Structure of RsmE bound to the… · the same entry in another collection · chain C against C, TM-score 1.00

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