MolNFT v1 · #41496 · protein + DNA

Structure of the wilms tumor suppressor protein zinc finger domain bound to DNA

2JPA · DNA (5'- D(P*DCP*DGP*DCP*DGP*DGP*DGP*DGP*DGP*DCP*DGP*DTP*DCP…: “Structure of the wilms tumor suppressor protein zinc finger domain bound to DNA”. Solution nmr, 1 ligand (ZN). MolNFT v1 #41496 on GenesisL1: 3D structure, binding…

PDB: 2JPA
Type: protein + DNA
Length: 147 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA (5'- D(P*DCP*DGP*DCP*DGP*DGP*DGP*DGP*DGP*DCP*DGP*DTP*DCP*DTP*DG)-3'); DNA (5'…
UniProt: Q4VXV4
Ligands: ZN

Structure

solution nmr · 3 distinct chains · 38% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	DNA (5'- D(PDCPDGPDCPDGPDGPDGPDGPDGPDCPDGPDTPDCPDTPDG)-3')	dna	14	—	—
C	DNA (5'- D(PDCPDAPDGPDAPDCPDGPDCPDCPDCPDCPDCPDGPDCPDG)-3')	dna	14	—	—
A	Wilms tumor 1	protein	119	38% helix, 13% strand	Q4VXV4

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

3 interfaces between chains.

B–A · 1113 Å² buried · 29 hydrogen bonds · protein-nucleic
C–A · 905 Å² buried · 18 hydrogen bonds · protein-nucleic
B–C · 653 Å² buried · 68 hydrogen bonds · nucleic-nucleic

Compared structures

2JPA · Structure of the Wilms Tumor Suppressor Protein Zinc Finger Domain Bound to DNA · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4VXV4
Elsewhere: RCSB PDB 2JPA · PDBe 2JPA · UniProt Q4VXV4

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