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Structure of the wilms tumor suppressor protein zinc finger domain bound to DNA

Analyse Structure of the wilms tumor suppressor protein zinc finger domain bound to DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2JPA
Type: protein + DNA
Length: 147 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA (5'- D(P*DCP*DGP*DCP*DGP*DGP*DGP*DGP*DGP*DCP*DGP*DTP*DCP*DTP*DG)-3'); DNA (5'…
UniProt: Q4VXV4
Ligands: ZN

Structure

solution nmr · 3 distinct chains · 38% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	DNA (5'- D(PDCPDGPDCPDGPDGPDGPDGPDGPDCPDGPDTPDCPDTPDG)-3')	dna	14	—	—
C	DNA (5'- D(PDCPDAPDGPDAPDCPDGPDCPDCPDCPDCPDCPDGPDCPDG)-3')	dna	14	—	—
A	Wilms tumor 1	protein	119	38% helix, 13% strand	Q4VXV4

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

3 interfaces between chains.

B–A · 1113 Å² buried · 29 hydrogen bonds · protein-nucleic
C–A · 905 Å² buried · 18 hydrogen bonds · protein-nucleic
B–C · 653 Å² buried · 68 hydrogen bonds · nucleic-nucleic

Compared structures

2JPA · Structure of the Wilms Tumor Suppressor Protein Zinc Finger Domain Bound to DNA · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4VXV4
Elsewhere: RCSB PDB 2JPA · PDBe 2JPA · UniProt Q4VXV4

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