MolNFT v1 · #41440 · protein

Solution structure of the P8 tfiih subunit

2JNJ · Tfiih basal transcription factor complex ttd-a subunit: “Solution structure of the P8 tfiih subunit”. Solution nmr, 1 pocket (best druggability 0.35). MolNFT v1 #41440 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2JNJ
Type: protein
Length: 148 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tfiih basal transcription factor complex ttd-a subunit
UniProt: Q6ZYL4
Pockets: 1 · best druggability 0.35

Structure

solution nmr · 1 distinct chain · 34% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Tfiih basal transcription factor complex ttd-a subunit	protein	74	34% helix, 24% strand	Q6ZYL4

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.35	0.77	13	empty

Interfaces

1 interface between chains.

A–B · 832 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

2JNJ · Solution structure of the p8 TFIIH subunit · the same entry in another collection · chain A against A, TM-score 1.00
Q6ZYL4 · AlphaFold monomer V2.0 prediction for general transcription factor iih subunit 5 (Q6ZYL4) · a predicted model of the same protein · chain A against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6ZYL4
Elsewhere: RCSB PDB 2JNJ · PDBe 2JNJ · UniProt Q6ZYL4

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