MolNFT v1 · #41420 · protein
Oscp-nt (1-120) in complex with N-terminal (1-25) alpha subunit from F1-ATPase
2JMX · ATP synthase O subunit, mitochondrial: “Oscp-nt (1-120) in complex with N-terminal (1-25) alpha subunit from F1-ATPase”. Solution nmr, 1 pocket (best druggability 0.52). MolNFT v1 #41420 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2JMX
- Type
- protein
- Length
- 145 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP synthase O subunit, mitochondrial; ATP synthase subunit alpha heart isoform…
- EC
- 3.6.3.14
- UniProt
- P13621, P19483
- Pockets
- 1 · best druggability 0.52
Structure
solution nmr · 2 distinct chains · 59% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP synthase O subunit, mitochondrial (EC 3.6.3.14) | protein | 120 | 63% helix, 0% strand | P13621 |
| B | ATP synthase subunit alpha heart isoform, mitochondrial (EC 3.6.3.14) | protein | 25 | 36% helix, 0% strand | P19483 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 69 | 0.52 | 0.85 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 503 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2JMX · OSCP-NT (1-120) in complex with N-terminal (1-25) alpha subunit from F1-ATPase · the same entry in another collection · chain A against A, TM-score 1.00
- P13621 · AlphaFold monomer V2.0 prediction for ATP synthase subunit O, mitochondrial (P13621) · a predicted model of the same protein · chain A against A, TM-score 0.72
- P19483 · AlphaFold monomer V2.0 prediction for ATP synthase subunit alpha, mitochondrial (P19483) · a predicted model of the same protein · chain B against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13621
- Every structure of UniProt P19483
- Elsewhere: RCSB PDB 2JMX · PDBe 2JMX · UniProt P13621 · UniProt P19483
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