MolNFT v1 · #41072 · protein
Crystal structure of alpha-1,3 galactosyltransferase (C-terminus truncated mutant-C3) in complex with udp and tris
2JCJ · N-acetyllactosaminide alpha-1,3-galactosyltransferase: “Crystal structure of alpha-1,3 galactosyltransferase (C-terminus truncated mutant-C3) in complex with udp and…”. X-ray diffraction, 2 ligands (UDP, MN), 2 pockets (best…
- PDB
- 2JCJ
- Type
- protein
- Length
- 284 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- N-acetyllactosaminide alpha-1,3-galactosyltransferase
- EC
- 2.4.1.151
- UniProt
- P14769
- Ligands
- UDP, MN
- Pockets
- 2 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | N-acetyllactosaminide alpha-1,3-galactosyltransferase (EC 2.4.1.151) | protein | 284 | 35% helix, 21% strand | P14769 |
Ligands and binding sites
- UDP · Uridine-5'-diphosphate · ligand · chains A
- MN · Manganese (II) ion · metal · chains A
- MPD · (4S)-2-methyl-2,4-pentanediol · additive · chains A
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 289 | 0.72 | 0.86 | 33 | UDP, MN, TRS |
| 2 | 61 | 0.29 | 0.74 | 15 | empty |
Compared structures
- 2JCJ · Crystal structure of alpha-1,3 Galactosyltransferase (C-terminus truncated mutant-C3) in… · the same entry in another collection · chain A against A, TM-score 1.00
- P14769 · AlphaFold monomer V2.0 prediction for N-acetyllactosaminide… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14769
- Elsewhere: RCSB PDB 2JCJ · PDBe 2JCJ · UniProt P14769
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