MolNFT v1 · #41012 · protein

Human PP2A regulatory subunit B56G

2JAK · SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory…: “Human PP2A regulatory subunit B56G”. X-ray diffraction, 3 pockets (best druggability 0.48). MolNFT v1 #41012 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2JAK
Type: protein
Length: 327 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory subunit gamma isoform
UniProt: Q13362
Pockets: 3 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 68% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory subunit gamma isoform	protein	327	68% helix, 0% strand	Q13362

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	62	0.48	0.84	12	empty
2	82	0.41	0.79	12	empty
3	76	0.38	0.77	18	empty

Compared structures

2JAK · Human PP2A regulatory subunit B56g · the same entry in another collection · chain A against A, TM-score 1.00
Q13362 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A 56 kda… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13362
Elsewhere: RCSB PDB 2JAK · PDBe 2JAK · UniProt Q13362

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