MolNFT v1 · #40917 · protein

Structure of the rnai polymerase from neurospora crassa

2J7N · RNA-dependent RNA polymerase: “Structure of the rnai polymerase from neurospora crassa”. X-ray diffraction, 1 ligand (MG), 20 pockets (best druggability 0.79). MolNFT v1 #40917 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 2J7N
Type: protein
Length: 1,865 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-dependent RNA polymerase
UniProt: Q9Y7G6
Ligands: MG
Pockets: 20 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-dependent RNA polymerase	protein	934	41% helix, 18% strand	Q9Y7G6
B	RNA-dependent RNA polymerase	protein	931	39% helix, 17% strand	Q9Y7G6

Ligands and binding sites

MG · Magnesium ion · metal · 2 copies · chains A, B
GOL · Glycerol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	96	0.79	0.99	20	GOL
2	390	0.66	0.80	47	empty
3	347	0.66	0.80	42	empty
4	498	0.64	0.77	57	empty
5	74	0.63	0.91	22	empty

Interfaces

1 interface between chains.

A–B · 4578 Å² buried · 40 hydrogen bonds · protein-protein

Compared structures

2J7N · Structure of the RNAi polymerase from Neurospora crassa · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y7G6
Elsewhere: RCSB PDB 2J7N · PDBe 2J7N · UniProt Q9Y7G6

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