MolNFT v1 · #40890 · protein

R164N mutant of the RUNX1 runt domain

2J6W · Runt-related transcription factor 1: “R164N mutant of the RUNX1 runt domain”. X-ray diffraction, 1 ligand (CL). MolNFT v1 #40890 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2J6W
Type: protein
Length: 248 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Runt-related transcription factor 1
UniProt: Q03347
Ligands: CL

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Runt-related transcription factor 1	protein	124	6% helix, 42% strand	Q03347

Ligands and binding sites

CL · Chloride ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 221 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

2J6W · R164N mutant of the RUNX1 Runt domain · the same entry in another collection · chain A against A, TM-score 1.00
Q03347 · AlphaFold monomer V2.0 prediction for runt-related transcription factor 1 (Q03347) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q03347
Elsewhere: RCSB PDB 2J6W · PDBe 2J6W · UniProt Q03347

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