MolNFT v1 · #40717 · protein
P53 tetramerization domain mutant T329F Q331K
2J10 · Cellular tumor antigen P53: “P53 tetramerization domain mutant T329F Q331K”. Solution nmr, 2 pockets (best druggability 0.49). MolNFT v1 #40717 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2J10
- Type
- protein
- Length
- 124 residues
- Chains
- 4
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cellular tumor antigen P53
- UniProt
- P04637
- Pockets
- 2 · best druggability 0.49
Structure
solution nmr · 1 distinct chain · 68% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Cellular tumor antigen P53 | protein | 31 | 68% helix, 16% strand | P04637 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 75 | 0.49 | 0.83 | 20 | empty |
| 2 | 100 | 0.39 | 0.76 | 17 | empty |
Interfaces
6 interfaces between chains.
- C–D · 1228 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1071 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 323 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 320 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 91 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2J10 · p53 tetramerization domain mutant T329F Q331K · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04637
- Elsewhere: RCSB PDB 2J10 · PDBe 2J10 · UniProt P04637
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