MolNFT v1 · #40711 · protein
The crystal structure of EIF4AIII-barentsz complex at 3.0 a resolution
2J0U · ATP-dependent RNA helicase DDX48: “The crystal structure of EIF4AIII-barentsz complex at 3.0 a resolution”. X-ray diffraction, 14 pockets (best druggability 0.76). MolNFT v1 #40711 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2J0U
- Type
- protein
- Length
- 722 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent RNA helicase DDX48; Protein CASC3
- UniProt
- P38919, O15234
- Pockets
- 14 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 39% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-dependent RNA helicase DDX48 | protein | 366 | 40% helix, 16% strand | P38919 |
| B | ATP-dependent RNA helicase DDX48 | protein | 347 | 40% helix, 15% strand | P38919 |
| T | Protein CASC3 | protein | 9 | 0% helix, 0% strand | O15234 |
Pockets
14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 516 | 0.76 | 0.83 | 53 | empty |
| 2 | 426 | 0.65 | 0.78 | 58 | empty |
| 3 | 364 | 0.63 | 0.78 | 45 | empty |
| 4 | 121 | 0.62 | 0.87 | 31 | empty |
| 5 | 128 | 0.60 | 0.85 | 28 | empty |
Interfaces
2 interfaces between chains.
- A–T · 554 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 445 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2J0U · The crystal structure of eIF4AIII-Barentsz complex at 3.0 A resolution · the same entry in another collection · chain A against A, TM-score 1.00
- P38919 · AlphaFold monomer V2.0 prediction for eukaryotic initiation factor 4A-III (P38919) · a predicted model of the same protein · chain B against A, TM-score 0.56
- O15234 · AlphaFold monomer V2.0 prediction for protein CASC3 (O15234) · a predicted model of the same protein · chain T against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38919
- Every structure of UniProt O15234
- Elsewhere: RCSB PDB 2J0U · PDBe 2J0U · UniProt P38919 · UniProt O15234
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