UniProt O15234

Protein CASC3 (O15234)

Protein CASC3 (UniProt O15234): 22 experimental structures and 1 predicted model on GenesisL1, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: O15234
Protein: Protein CASC3
Experimental structures: 22
Predicted models: 1
Pockets: 2 · 2 records with a druggable one

Structures

23 records of O15234 in the MolNFT archive: 22 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
2HYI	Structure of the human exon junction complex with a trapped DEAD-box helicase bound to RNA	x-ray diffraction	D, J	—	—
2HYI	Structure of the human exon junction complex with a trapped dead-box helicase bound to RNA	x-ray diffraction	D, J	—	—
2J0Q	The crystal structure of the Exon Junction Complex at 3.2 A resolution	x-ray diffraction	I, T	—	—
2J0Q	The crystal structure of the exon junction complex at 3.2 a resolution	x-ray diffraction	I, T	—	—
2J0S	The crystal structure of the Exon Junction Complex at 2.2 A resolution	x-ray diffraction	T	—	—
2J0S	The crystal structure of the exon junction complex at 2.2 a resolution	x-ray diffraction	T	—	—
2J0U	The crystal structure of eIF4AIII-Barentsz complex at 3.0 A resolution	x-ray diffraction	T	—	—
2J0U	The crystal structure of EIF4AIII-barentsz complex at 3.0 a resolution	x-ray diffraction	T	—	—
2XB2	Crystal structure of the core Mago-Y14-eIF4AIII-Barentsz-UPF3b assembly shows how the EJC is…	x-ray diffraction	S, T	—	—
2XB2	Crystal structure of the core mago-Y14-EIF4AIII-barentsz- UPF3B assembly shows how the ejc is…	x-ray diffraction	S, T	—	—
3EX7	The crystal structure of EJC in its transition state	x-ray diffraction	D, I	—	—
3EX7	The crystal structure of ejc in its transition state	x-ray diffraction	D, I	—	—
5XJC	Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom	electron microscopy	x	—	—
5YZG	The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolution	electron microscopy	x	—	—
6ICZ	Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom	electron microscopy	x	—	—
6ICZ	Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 ångström	electron microscopy	x	—	—
7W59	The cryo-EM structure of human pre-C*-I complex	electron microscopy	x	—	1 (best 0.80)
7W59	The cryo-EM structure of human pre-C*-I complex	electron microscopy	x	—	—
7W5A	The cryo-EM structure of human pre-C*-II complex	electron microscopy	x	—	—
7W5A	The cryo-EM structure of human pre-C*-II complex	electron microscopy	x	—	—
7W5B	The cryo-EM structure of human C* complex	electron microscopy	x	—	1 (best 0.85)
8I0W	The cryo-EM structure of human C complex	electron microscopy	x	—	—
O15234	AlphaFold monomer V2.0 prediction for protein CASC3 (O15234)	predicted	A	—	—

Experiment against prediction

7W5A chain x against the predicted model O15234: TM-score 0.91, RMSD 0.29 Å
7W5A chain x against the predicted model O15234: TM-score 0.91, RMSD 0.29 Å
7W59 chain x against the predicted model O15234: TM-score 0.91, RMSD 0.29 Å
7W59 chain x against the predicted model O15234: TM-score 0.91, RMSD 0.29 Å
7W5B chain x against the predicted model O15234: TM-score 0.91, RMSD 0.29 Å
6ICZ chain x against the predicted model O15234: TM-score 0.91, RMSD 0.29 Å
6ICZ chain x against the predicted model O15234: TM-score 0.91, RMSD 0.29 Å
5YZG chain x against the predicted model O15234: TM-score 0.91, RMSD 0.29 Å
5XJC chain x against the predicted model O15234: TM-score 0.91, RMSD 0.29 Å
8I0W chain x against the predicted model O15234: TM-score 0.88, RMSD 0.34 Å

Elsewhere

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