MolNFT v1 · #40655 · protein
Function and structure of the molybdenum cofactor carrier protein mcp from chlamydomonas reinhardtii
2IZ5 · Moco carrier protein: “Function and structure of the molybdenum cofactor carrier protein mcp from chlamydomonas reinhardtii”. X-ray diffraction, 6 pockets (best druggability 0.64). MolNFT v1 #40655 on GenesisL1: 3D structure…
- PDB
- 2IZ5
- Type
- protein
- Length
- 639 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Moco carrier protein
- UniProt
- Q8RV61
- Pockets
- 6 · best druggability 0.64
Structure
x-ray diffraction · 4 distinct chains · 43% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Moco carrier protein | protein | 160 | 44% helix, 20% strand | Q8RV61 |
| B | Moco carrier protein | protein | 161 | 42% helix, 20% strand | Q8RV61 |
| C | Moco carrier protein | protein | 158 | 44% helix, 20% strand | Q8RV61 |
| D | Moco carrier protein | protein | 160 | 42% helix, 20% strand | Q8RV61 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 330 | 0.64 | 0.80 | 38 | empty |
| 2 | 243 | 0.62 | 0.81 | 34 | empty |
| 3 | 225 | 0.59 | 0.80 | 35 | empty |
| 4 | 236 | 0.58 | 0.79 | 30 | empty |
| 5 | 96 | 0.35 | 0.74 | 19 | empty |
Interfaces
6 interfaces between chains.
- B–C · 836 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 834 Ų buried · 10 hydrogen bonds · protein-protein
- A–D · 780 Ų buried · 1 hydrogen bond · protein-protein
- C–D · 701 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 178 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2IZ5 · Function and structure of the molybdenum cofactor carrier protein mcp from chlamydomonas… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8RV61
- Elsewhere: RCSB PDB 2IZ5 · PDBe 2IZ5 · UniProt Q8RV61
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