MolNFT v1 · #40605 · protein

Structure of human ptpa

2IXM · SERINE/THREONINE-protein phosphatase 2A regulatory subunit…: “Structure of human ptpa”. X-ray diffraction, 2 pockets (best druggability 0.66). MolNFT v1 #40605 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2IXM
Type: protein
Length: 300 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein phosphatase 2A regulatory subunit B'
UniProt: Q15257
Pockets: 2 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 62% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein phosphatase 2A regulatory subunit B'	protein	300	62% helix, 4% strand	Q15257

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	176	0.66	0.86	39	empty
2	119	0.51	0.81	25	empty

Compared structures

2IXM · Structure of human PTPA · the same entry in another collection · chain A against A, TM-score 1.00
Q15257 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A activator… · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15257
Elsewhere: RCSB PDB 2IXM · PDBe 2IXM · UniProt Q15257

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