MolNFT v1 · #40572 · protein

12TH PDZ domain of multiple PDZ domain protein mpdz (casp target)

2IWP: “12TH PDZ domain of multiple PDZ domain protein mpdz (casp target)”. X-ray diffraction, 1 pocket (best druggability 0.31). MolNFT v1 #40572 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2IWP
Type: protein
Length: 198 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Multiple PDZ domain protein
UniProt: O75970
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 18% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Multiple PDZ domain protein	protein	92	16% helix, 48% strand	O75970
B	Multiple PDZ domain protein	protein	106	19% helix, 42% strand	O75970

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	58	0.31	0.76	22	empty

Interfaces

1 interface between chains.

A–B · 1204 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

2IWP · 12th PDZ domain of Multiple PDZ Domain Protein MPDZ · the same entry in another collection · chain A against A, TM-score 1.00
O75970 · AlphaFold monomer V2.0 prediction for multiple PDZ domain protein (O75970) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75970
Elsewhere: RCSB PDB 2IWP · PDBe 2IWP · UniProt O75970

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