MolNFT v1 · #40387 · protein
Unliganded crystal structure of the uridine phosphorylase from salmonella typhimurium at 1.90 a resolution
2IQ5: “Unliganded crystal structure of the uridine phosphorylase from salmonella typhimurium at 1.90 a resolution”. X-ray diffraction, 3 pockets (best druggability 0.72). MolNFT v1 #40387 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2IQ5
- Type
- protein
- Length
- 475 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uridine phosphorylase
- EC
- 2.4.2.3
- UniProt
- P0A1F6
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uridine phosphorylase (EC 2.4.2.3) | protein | 250 | 34% helix, 29% strand | P0A1F6 |
| B | Uridine phosphorylase (EC 2.4.2.3) | protein | 225 | 32% helix, 32% strand | P0A1F6 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 495 | 0.72 | 0.81 | 44 | empty |
| 2 | 385 | 0.66 | 0.80 | 53 | empty |
| 3 | 78 | 0.33 | 0.75 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 1540 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 2IQ5 · Unliganded Crystal Structure of the Uridine Phosphorylase from Salmonella Typhimurium at… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A1F6
- Elsewhere: RCSB PDB 2IQ5 · PDBe 2IQ5 · UniProt P0A1F6
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