MolNFT v1 · #40255 · protein

Three-dimensional structure of interleukin 8 in solution

2IL8 · Interleukin-8: “Three-dimensional structure of interleukin 8 in solution”. Solution nmr, 1 pocket (best druggability 0.62). MolNFT v1 #40255 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2IL8
Type: protein
Length: 142 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-8
UniProt: P10145
Pockets: 1 · best druggability 0.62

Structure

solution nmr · 1 distinct chain · 27% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Interleukin-8	protein	71	27% helix, 28% strand	P10145

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	169	0.62	0.84	26	empty

Interfaces

1 interface between chains.

A–B · 890 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

2IL8 · Three-dimensional structure of interleukin 8 in solution · the same entry in another collection · chain A against A, TM-score 1.00
P10145 · AlphaFold monomer V2.0 prediction for interleukin-8 (P10145) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10145
Elsewhere: RCSB PDB 2IL8 · PDBe 2IL8 · UniProt P10145

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