MolNFT v1 · #40172 · protein

Crystal structure of catalytic domain of son of sevenless (rem-CDC25) in the absence of RAS

2II0 · Son of sevenless homolog 1: “Crystal structure of catalytic domain of son of sevenless (rem-CDC25) in the absence of RAS”. X-ray diffraction, 5 pockets (best druggability 0.39). MolNFT v1 #40172 on GenesisL1: 3D structure, binding…

PDB: 2II0
Type: protein
Length: 463 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Son of sevenless homolog 1
UniProt: Q07889
Pockets: 5 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 60% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Son of sevenless homolog 1	protein	463	60% helix, 4% strand	Q07889

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	79	0.39	0.78	19	empty
2	77	0.36	0.76	12	empty
3	80	0.36	0.76	18	empty
4	51	0.33	0.78	13	empty
5	53	0.31	0.77	15	empty

Compared structures

2II0 · Crystal Structure of catalytic domain of Son of sevenless (Rem-Cdc25) in the absence of… · the same entry in another collection · chain A against A, TM-score 1.00
Q07889 · AlphaFold monomer V2.0 prediction for son of sevenless homolog 1 (Q07889) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07889
Elsewhere: RCSB PDB 2II0 · PDBe 2II0 · UniProt Q07889

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