MolNFT v1 · #40163 · protein

RF2 of thermus thermophilus

2IHR · Peptide chain release factor 2: “RF2 of thermus thermophilus”. X-ray diffraction, 5 pockets (best druggability 0.59). MolNFT v1 #40163 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2IHR
Type: protein
Length: 351 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peptide chain release factor 2
UniProt: Q5SM01
Pockets: 5 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
1	Peptide chain release factor 2	protein	351	40% helix, 21% strand	Q5SM01

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	449	0.59	0.75	31	empty
2	201	0.48	0.75	33	empty
3	60	0.42	0.81	14	empty
4	107	0.39	0.75	13	empty
5	77	0.33	0.75	16	empty

Compared structures

2IHR · RF2 of Thermus thermophilus · the same entry in another collection · chain 1 against 1, TM-score 1.00
Q5SM01 · AlphaFold monomer V2.0 prediction for peptide chain release factor RF2 (Q5SM01) · a predicted model of the same protein · chain 1 against A, TM-score 0.70

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5SM01
Elsewhere: RCSB PDB 2IHR · PDBe 2IHR · UniProt Q5SM01

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