MolNFT v1 · #40052 · protein

Annexin V under 2.0 mpa pressure of nitrous oxide

2IE7 · Annexin A5: “Annexin V under 2.0 mpa pressure of nitrous oxide”. X-ray diffraction, 3 ligands (CA, SO4, N2O), 4 pockets (best druggability 0.53). MolNFT v1 #40052 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2IE7
Type: protein
Length: 318 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin A5
UniProt: P14668
Ligands: CA, SO4, N2O
Pockets: 4 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin A5	protein	318	72% helix, 0% strand	P14668

Ligands and binding sites

CA · Calcium ion · metal · 7 copies · chains A
SO4 · Sulfate ion · ion · 4 copies · chains A
N2O · Nitrous oxide · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	101	0.53	0.84	28	SO4
2	92	0.47	0.81	20	empty
3	158	0.46	0.76	19	empty
4	58	0.32	0.76	12	empty

Compared structures

2IE7 · Annexin V under 2.0 MPa pressure of nitrous oxide · the same entry in another collection · chain A against A, TM-score 1.00
P14668 · AlphaFold monomer V2.0 prediction for annexin A5 (P14668) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14668
Elsewhere: RCSB PDB 2IE7 · PDBe 2IE7 · UniProt P14668

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