MolNFT v1 · #39535 · protein

Structure of human SMG6 E1282C pin domain mutant.

2HWX · Telomerase-binding protein EST1A: “Structure of human SMG6 E1282C pin domain mutant.”. X-ray diffraction, 3 pockets (best druggability 0.39). MolNFT v1 #39535 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2HWX
Type: protein
Length: 165 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Telomerase-binding protein EST1A
UniProt: Q86US8
Pockets: 3 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Telomerase-binding protein EST1A	protein	165	48% helix, 19% strand	Q86US8

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.39	0.79	20	empty
2	50	0.30	0.76	13	empty
3	59	0.30	0.75	15	empty

Compared structures

2HWX · Structure of human SMG6 E1282C PIN domain mutant. · the same entry in another collection · chain A against A, TM-score 1.00
Q86US8 · AlphaFold monomer V2.0 prediction for telomerase-binding protein EST1A (Q86US8) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86US8
Elsewhere: RCSB PDB 2HWX · PDBe 2HWX · UniProt Q86US8

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.