UniProt Q86US8
Telomerase-binding protein EST1A (Q86US8)
Telomerase-binding protein EST1A (UniProt Q86US8), EC 3.1.-.-: 9 experimental structures and 1 predicted model on GenesisL1, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q86US8
- Protein
- Telomerase-binding protein EST1A
- EC
- 3.1.-.-
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 4 · 1 record with a druggable one
Structures
10 records of Q86US8 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2DOK | Crystal structure of the PIN domain of human EST1A | x-ray diffraction | A, B | — | — |
| 2DOK | Crystal structure of the pin domain of human EST1A | x-ray diffraction | A, B | — | — |
| 2HWW | Structure of PIN domain of human SMG6 | x-ray diffraction | A, B, C | — | — |
| 2HWW | Structure of pin domain of human SMG6 | x-ray diffraction | A, B, C | — | — |
| 2HWX | Structure of human SMG6 E1282C PIN domain mutant. | x-ray diffraction | A | — | — |
| 2HWX | Structure of human SMG6 E1282C pin domain mutant. | x-ray diffraction | A | — | — |
| 4UM2 | Crystal structure of the TPR domain of SMG6 | x-ray diffraction | A | — | — |
| 4UM2 | Crystal structure of the tpr domain of SMG6 | x-ray diffraction | A | — | — |
| 8RXB | Human UPF1 CH domain in complex with SMG6 peptide | x-ray diffraction | F, B, G, J, N, Q | — | 4 (best 0.64) |
| Q86US8 | AlphaFold monomer V2.0 prediction for telomerase-binding protein EST1A (Q86US8) | predicted | A | — | — |
Experiment against prediction
- 4UM2 chain A against the predicted model Q86US8: TM-score 0.98, RMSD 1.07 Å
- 4UM2 chain A against the predicted model Q86US8: TM-score 0.98, RMSD 1.07 Å
- 2HWW chain B against the predicted model Q86US8: TM-score 0.96, RMSD 1.31 Å
- 2HWW chain B against the predicted model Q86US8: TM-score 0.96, RMSD 1.31 Å
- 2HWW chain A against the predicted model Q86US8: TM-score 0.95, RMSD 1.42 Å
- 2HWW chain A against the predicted model Q86US8: TM-score 0.95, RMSD 1.42 Å
- 2HWW chain C against the predicted model Q86US8: TM-score 0.94, RMSD 1.61 Å
- 2HWW chain C against the predicted model Q86US8: TM-score 0.94, RMSD 1.61 Å
- 2DOK chain A against the predicted model Q86US8: TM-score 0.93, RMSD 1.60 Å
- 2DOK chain A against the predicted model Q86US8: TM-score 0.93, RMSD 1.60 Å
Elsewhere
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