MolNFT v1 · #39070 · protein
Crystal structure of staphylococcus hyicus lipase
2HIH · Lipase 46 kda form: “Crystal structure of staphylococcus hyicus lipase”. X-ray diffraction, 2 ligands (ZN, CA), 8 pockets (best druggability 0.85). MolNFT v1 #39070 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2HIH
- Type
- protein
- Length
- 773 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lipase 46 kda form
- EC
- 3.1.1.3
- UniProt
- P04635
- Ligands
- ZN, CA
- Pockets
- 8 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lipase 46 kda form (EC 3.1.1.3) | protein | 387 | 41% helix, 14% strand | P04635 |
| B | Lipase 46 kda form (EC 3.1.1.3) | protein | 386 | 39% helix, 14% strand | P04635 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1011 | 0.85 | 0.86 | 71 | empty |
| 2 | 1186 | 0.84 | 0.84 | 67 | empty |
| 3 | 165 | 0.57 | 0.81 | 21 | empty |
| 4 | 153 | 0.57 | 0.82 | 20 | empty |
| 5 | 149 | 0.53 | 0.80 | 37 | empty |
Interfaces
1 interface between chains.
- A–B · 1334 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04635
- Elsewhere: RCSB PDB 2HIH · PDBe 2HIH · UniProt P04635
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