MolNFT v1 · #38866 · protein
Crystal structure of hif prolyl hydroxylase egln-1 in complex with a biologically active inhibitor
2HBT · Egl nine homolog 1: “Crystal structure of hif prolyl hydroxylase egln-1 in complex with a biologically active inhibitor”. X-ray diffraction, 2 ligands (UN9, FE2), 1 pocket (best druggability 0.65). MolNFT v1 #38866 on GenesisL1: 3D…
- PDB
- 2HBT
- Type
- protein
- Length
- 224 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Egl nine homolog 1
- EC
- 1.14.11.-
- UniProt
- Q9GZT9
- Ligands
- UN9, FE2
- Pockets
- 1 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 27% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Egl nine homolog 1 (EC 1.14.11.-) | protein | 224 | 27% helix, 29% strand | Q9GZT9 |
Ligands and binding sites
- UN9 · N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine · ligand · chains A
- FE2 · Fe (II) ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 122 | 0.65 | 0.88 | 22 | FE2, UN9 |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2HBT · Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9GZT9 · AlphaFold monomer V2.0 prediction for egl nine homolog 1 (Q9GZT9) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9GZT9
- Elsewhere: RCSB PDB 2HBT · PDBe 2HBT · UniProt Q9GZT9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.