MolNFT v1 · #38832 · protein
Apo-human serum transferrin (non-glycosylated)
2HAU · Serotransferrin: “Apo-human serum transferrin (non-glycosylated)”. X-ray diffraction, 11 pockets (best druggability 0.77). MolNFT v1 #38832 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2HAU
- Type
- protein
- Length
- 1,352 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serotransferrin
- UniProt
- P02787
- Pockets
- 11 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Serotransferrin | protein | 676 | 33% helix, 18% strand | P02787 |
Ligands and binding sites
- CIT · Citric acid · additive · 4 copies · chains A, B
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 920 | 0.77 | 0.80 | 78 | empty |
| 2 | 901 | 0.75 | 0.78 | 68 | empty |
| 3 | 707 | 0.69 | 0.76 | 54 | CIT |
| 4 | 669 | 0.68 | 0.76 | 70 | empty |
| 5 | 93 | 0.42 | 0.78 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1104 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 38 disulfide, 18 modified (disulfide, engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02787
- Elsewhere: RCSB PDB 2HAU · PDBe 2HAU · UniProt P02787
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