MolNFT v1 · #38605 · protein

Solution structure of the HIV-1 myristoylated matrix protein

2H3I · Gag polyprotein: “Solution structure of the HIV-1 myristoylated matrix protein”. Solution nmr, 1 ligand (MYR), 2 pockets (best druggability 0.50). MolNFT v1 #38605 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2H3I
Type: protein
Length: 131 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gag polyprotein
UniProt: P12497
Ligands: MYR
Pockets: 2 · best druggability 0.50

Structure

solution nmr · 1 distinct chain · 56% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gag polyprotein	protein	131	56% helix, 2% strand	P12497

Ligands and binding sites

MYR · Myristic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.50	0.85	15	MYR
2	59	0.33	0.77	10	empty

Modifications

Observed in the structure: 1 lipid (myristoylation).

Compared structures

2H3I · Solution structure of the HIV-1 myristoylated Matrix protein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12497
Elsewhere: RCSB PDB 2H3I · PDBe 2H3I · UniProt P12497

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