MolNFT v1 · #38400 · protein

Crystal structure of the yeast TOM70

2GW1 · Mitochondrial precursor proteins import receptor: “Crystal structure of the yeast TOM70”. X-ray diffraction, 18 pockets (best druggability 0.80). MolNFT v1 #38400 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2GW1
Type: protein
Length: 974 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitochondrial precursor proteins import receptor
UniProt: P07213
Pockets: 18 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Mitochondrial precursor proteins import receptor	protein	487	73% helix, 0% strand	P07213

Pockets

18 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1130	0.80	0.81	119	empty
2	753	0.76	0.81	73	empty
3	269	0.56	0.77	44	empty
4	221	0.55	0.77	30	empty
5	251	0.53	0.76	40	empty

Interfaces

1 interface between chains.

A–B · 2185 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2GW1 · Crystal Structure of the Yeast Tom70 · the same entry in another collection · chain A against A, TM-score 1.00
P07213 · AlphaFold monomer V2.0 prediction for mitochondrial import receptor subunit TOM70 (P07213) · a predicted model of the same protein · chain A against A, TM-score 0.77

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07213
Elsewhere: RCSB PDB 2GW1 · PDBe 2GW1 · UniProt P07213

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