MolNFT v1 · #38353 · DNA + RNA

RNA-binding affinities and crystal structure of oligonucleotides containing five-atom amide-based backbone structures

2GUN · 5'-D(*TP*TP*CP*(T2T)P*(CBR)P*TP*TP*C)-3': “RNA-binding affinities and crystal structure of oligonucleotides containing five-atom amide-based backbone…”. X-ray diffraction, 2 ligands (SPM, 3CO). MolNFT v1 #38353 on GenesisL1: 3D…

PDB: 2GUN
Type: DNA + RNA
Length: 17 nucleotides
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-D(*TP*TP*CP*(T2T)P*(CBR)P*TP*TP*C)-3'; 5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*A)-3'
Ligands: SPM, 3CO

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	5'-D(TPTPCP(T2T)P(CBR)PTPTPC)-3'	dna	8	—	—
B	5'-R(GPAPAPGPAPAPGPAP*A)-3'	rna	9	—	—

Ligands and binding sites

SPM · Spermine · ligand · chains B
3CO · Cobalt (III) ion · metal · 2 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 419 Å² buried · 46 hydrogen bonds · nucleic-nucleic

Modifications

Observed in the structure: 2 modified (nucleotide modification).

Compared structures

2GUN · RNA-Binding Affinities and Crystal Structure of Oligonucleotides containing Five-Atom… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2GUN · PDBe 2GUN

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