MolNFT v1 · #38249 · protein
Crystal structure of PRGX/ICF10 complex
2GRM: “Crystal structure of PRGX/ICF10 complex”. X-ray diffraction, 8 pockets (best druggability 0.63). MolNFT v1 #38249 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2GRM
- Type
- protein
- Length
- 938 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prgx; Peptide
- Pockets
- 8 · best druggability 0.63
Structure
x-ray diffraction · 3 distinct chains · 69% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Prgx | protein | 315 | 71% helix, 1% strand | — |
| C | Prgx | protein | 294 | 70% helix, 1% strand | — |
| D, E | Peptide | protein | 7 | 0% helix, 29% strand | — |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 413 | 0.63 | 0.77 | 44 | empty |
| 2 | 304 | 0.58 | 0.77 | 29 | empty |
| 3 | 325 | 0.57 | 0.76 | 37 | empty |
| 4 | 149 | 0.55 | 0.81 | 23 | empty |
| 5 | 152 | 0.55 | 0.81 | 21 | empty |
Interfaces
4 interfaces between chains.
- B–E · 823 Ų buried · 16 hydrogen bonds · protein-protein
- A–D · 806 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 575 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 571 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2GRM · Crystal structure of PrgX/iCF10 complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2GRM · PDBe 2GRM
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.