Research workbench

Crystal structure of PRGX/ICF10 complex

Analyse Crystal structure of PRGX/ICF10 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2GRM
Type: protein
Length: 938 residues
Chains: 5
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prgx; Peptide
Pockets: 8 · best druggability 0.63

Structure

x-ray diffraction · 3 distinct chains · 69% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Prgx	protein	315	71% helix, 1% strand	—
C	Prgx	protein	294	70% helix, 1% strand	—
D, E	Peptide	protein	7	0% helix, 29% strand	—

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	413	0.63	0.77	44	empty
2	304	0.58	0.77	29	empty
3	325	0.57	0.76	37	empty
4	149	0.55	0.81	23	empty
5	152	0.55	0.81	21	empty

Interfaces

4 interfaces between chains.

B–E · 823 Å² buried · 16 hydrogen bonds · protein-protein
A–D · 806 Å² buried · 15 hydrogen bonds · protein-protein
B–C · 575 Å² buried · 2 hydrogen bonds · protein-protein
A–B · 571 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

2GRM · Crystal structure of PrgX/iCF10 complex · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2GRM · PDBe 2GRM

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.