MolNFT v1 · #38093 · protein
Structure of porcine electron transfer flavoprotein- ubiquinone oxidoreductase
2GMJ · Electron transfer flavoprotein-ubiquinone oxidoreductase: “Structure of porcine electron transfer flavoprotein- ubiquinone oxidoreductase”. X-ray diffraction, 2 ligands (SF4, FAD), 12 pockets (best druggability 0.86). MolNFT v1…
- PDB
- 2GMJ
- Type
- protein
- Length
- 1,159 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Electron transfer flavoprotein-ubiquinone oxidoreductase
- EC
- 1.5.5.1
- UniProt
- P55931
- Ligands
- SF4, FAD
- Pockets
- 12 · best druggability 0.86
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Electron transfer flavoprotein-ubiquinone oxidoreductase (EC 1.5.5.1) | protein | 581 | 27% helix, 22% strand | P55931 |
| B | Electron transfer flavoprotein-ubiquinone oxidoreductase (EC 1.5.5.1) | protein | 578 | 25% helix, 19% strand | P55931 |
Ligands and binding sites
- SF4 · Iron/sulfur cluster · ligand · 2 copies · chains A, B
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
- TBU · Tertiary-butyl alcohol · additive · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 415 | 0.86 | 0.94 | 62 | FAD |
| 2 | 427 | 0.86 | 0.94 | 61 | FAD |
| 3 | 856 | 0.83 | 0.85 | 82 | TBU |
| 4 | 958 | 0.72 | 0.76 | 77 | empty |
| 5 | 172 | 0.53 | 0.79 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 211 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2GMJ · Structure of Porcine Electron Transfer Flavoprotein-Ubiqui Oxidoreductase · the same entry in another collection · chain A against A, TM-score 1.00
- P55931 · AlphaFold monomer V2.0 prediction for electron transfer flavoprotein- ubiquinone… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55931
- Elsewhere: RCSB PDB 2GMJ · PDBe 2GMJ · UniProt P55931
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