MolNFT v1 · #38066 · protein + DNA

Solution structure of the brinker DNA binding domain in complex with the omb enhancer

2GLO · 5'-D(*TP*GP*AP*GP*GP*CP*GP*TP*CP*AP*AP*C)-3': “Solution structure of the brinker DNA binding domain in complex with the omb enhancer”. Solution nmr, 1 pocket (best druggability 0.34). MolNFT v1 #38066 on GenesisL1: 3D structure…

PDB: 2GLO
Type: protein + DNA
Length: 83 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-D(*TP*GP*AP*GP*GP*CP*GP*TP*CP*AP*AP*C)-3'; 5'-D(*GP*TP*TP*GP*AP*CP*GP*CP*CP*TP*CP*A)-3'…
UniProt: Q9XTN4
Pockets: 1 · best druggability 0.34

Structure

solution nmr · 3 distinct chains · 61% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	5'-D(TPGPAPGPGPCPGPTPCPAPAPC)-3'	dna	12	—	—
C	5'-D(GPTPTPGPAPCPGPCPCPTPCPA)-3'	dna	12	—	—
A	Brinker CG9653-pa	protein	59	61% helix, 0% strand	Q9XTN4

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	68	0.34	0.76	13	empty

Interfaces

3 interfaces between chains.

B–C · 557 Å² buried · 44 hydrogen bonds · nucleic-nucleic
B–A · 494 Å² buried · 21 hydrogen bonds · protein-nucleic
C–A · 473 Å² buried · 13 hydrogen bonds · protein-nucleic

Compared structures

2GLO · Solution structure of the Brinker DNA binding domain in complex with the omb enhancer · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9XTN4
Elsewhere: RCSB PDB 2GLO · PDBe 2GLO · UniProt Q9XTN4

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