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Solution structure of the brinker DNA binding domain in complex with the omb enhancer

Analyse Solution structure of the brinker DNA binding domain in complex with the omb… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2GLO
Type: protein + DNA
Length: 83 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-D(*TP*GP*AP*GP*GP*CP*GP*TP*CP*AP*AP*C)-3'; 5'-D(*GP*TP*TP*GP*AP*CP*GP*CP*CP*TP*CP*A)-3'…
UniProt: Q9XTN4
Pockets: 1 · best druggability 0.34

Structure

solution nmr · 3 distinct chains · 61% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	5'-D(TPGPAPGPGPCPGPTPCPAPAPC)-3'	dna	12	—	—
C	5'-D(GPTPTPGPAPCPGPCPCPTPCPA)-3'	dna	12	—	—
A	Brinker CG9653-pa	protein	59	61% helix, 0% strand	Q9XTN4

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	68	0.34	0.76	13	empty

Interfaces

3 interfaces between chains.

B–C · 557 Å² buried · 44 hydrogen bonds · nucleic-nucleic
B–A · 494 Å² buried · 21 hydrogen bonds · protein-nucleic
C–A · 473 Å² buried · 13 hydrogen bonds · protein-nucleic

Compared structures

2GLO · Solution structure of the Brinker DNA binding domain in complex with the omb enhancer · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9XTN4
Elsewhere: RCSB PDB 2GLO · PDBe 2GLO · UniProt Q9XTN4

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