MolNFT v1 · #37928 · protein
Crystal structure of human guanylate cyclase activating protein-3
2GGZ · Guanylyl cyclase-activating protein 3: “Crystal structure of human guanylate cyclase activating protein-3”. X-ray diffraction, 1 ligand (CA), 5 pockets (best druggability 0.73). MolNFT v1 #37928 on GenesisL1: 3D structure, binding…
- PDB
- 2GGZ
- Type
- protein
- Length
- 330 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanylyl cyclase-activating protein 3
- UniProt
- O95843
- Ligands
- CA
- Pockets
- 5 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 58% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Guanylyl cyclase-activating protein 3 | protein | 165 | 58% helix, 5% strand | O95843 |
Ligands and binding sites
- CA · Calcium ion · metal · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 144 | 0.73 | 0.91 | 21 | empty |
| 2 | 136 | 0.70 | 0.90 | 22 | empty |
| 3 | 186 | 0.55 | 0.79 | 27 | empty |
| 4 | 52 | 0.43 | 0.83 | 12 | empty |
| 5 | 86 | 0.41 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 489 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2GGZ · Crystal Structure of Human Guanylate Cyclase Activating Protein-3 · the same entry in another collection · chain A against A, TM-score 1.00
- O95843 · AlphaFold monomer V2.0 prediction for guanylyl cyclase-activating protein 3 (O95843) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95843
- Elsewhere: RCSB PDB 2GGZ · PDBe 2GGZ · UniProt O95843
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