MolNFT v1 · #37817 · protein
Crystal structure of covalently modified macrophage inhibitory factor
2GDG · Macrophage migration inhibitory factor: “Crystal structure of covalently modified macrophage inhibitory factor”. X-ray diffraction, 4 pockets (best druggability 0.82). MolNFT v1 #37817 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2GDG
- Type
- protein
- Length
- 342 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Macrophage migration inhibitory factor
- EC
- 5.3.2.1
- UniProt
- P34884
- Pockets
- 4 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Macrophage migration inhibitory factor (EC 5.3.2.1) | protein | 114 | 39% helix, 31% strand | P34884 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 409 | 0.82 | 0.90 | 52 | empty |
| 2 | 61 | 0.53 | 0.86 | 13 | empty |
| 3 | 54 | 0.50 | 0.86 | 13 | empty |
| 4 | 126 | 0.39 | 0.73 | 18 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1182 Ų buried · 23 hydrogen bonds · protein-protein
- A–C · 1126 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1112 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 2GDG · Crystal structure of covalently modified macrophage inhibitory factor · the same entry in another collection · chain A against A, TM-score 1.00
- P34884 · AlphaFold monomer V2.0 prediction for macrophage migration inhibitory factor (P34884) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P34884
- Elsewhere: RCSB PDB 2GDG · PDBe 2GDG · UniProt P34884
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