MolNFT v1 · #37792 · protein
Crystal structure of the human rhoc-gppnhp complex
2GCO · Rho-related GTP-binding protein rhoc: “Crystal structure of the human rhoc-gppnhp complex”. X-ray diffraction, 2 ligands (GNP, MG), 4 pockets (best druggability 0.57). MolNFT v1 #37792 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2GCO
- Type
- protein
- Length
- 370 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rho-related GTP-binding protein rhoc
- UniProt
- P08134
- Ligands
- GNP, MG
- Pockets
- 4 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rho-related GTP-binding protein rhoc | protein | 188 | 37% helix, 21% strand | P08134 |
| B | Rho-related GTP-binding protein rhoc | protein | 182 | 38% helix, 22% strand | P08134 |
Ligands and binding sites
- GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 125 | 0.57 | 0.84 | 22 | empty |
| 2 | 206 | 0.47 | 0.74 | 36 | empty |
| 3 | 122 | 0.41 | 0.75 | 26 | MG, GNP |
| 4 | 91 | 0.38 | 0.76 | 27 | MG, GNP |
Interfaces
1 interface between chains.
- A–B · 394 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (oxidation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08134
- Elsewhere: RCSB PDB 2GCO · PDBe 2GCO · UniProt P08134
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