MolNFT v1 · #37527 · protein + RNA

Structure of U2AF65 variant with polyuridine tract

2G4B · 5'-R(P*UP*UP*UP*UP*UP*UP*U)-3': “Structure of U2AF65 variant with polyuridine tract”. X-ray diffraction. MolNFT v1 #37527 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2G4B
Type: protein + RNA
Length: 179 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-R(P*UP*UP*UP*UP*UP*UP*U)-3'; Splicing factor U2AF 65 kda subunit
UniProt: P26368

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	5'-R(PUPUPUPUPUPUP*U)-3'	rna	7	—	—
A	Splicing factor U2AF 65 kda subunit	protein	172	26% helix, 31% strand	P26368

Ligands and binding sites

DIO · 1,4-diethylene dioxide · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

B–A · 591 Å² buried · 14 hydrogen bonds · protein-nucleic

Compared structures

2G4B · Structure of U2AF65 variant with polyuridine tract · the same entry in another collection · chain B against B, TM-score 1.00
P26368 · AlphaFold monomer V2.0 prediction for splicing factor U2AF 65 kda subunit (P26368) · a predicted model of the same protein · chain A against A, TM-score 0.53

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26368
Elsewhere: RCSB PDB 2G4B · PDBe 2G4B · UniProt P26368

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