MolNFT v1 · #37320 · protein

Structure of the human beta-myosin S2 fragment

2FXO · Myosin heavy chain, cardiac muscle beta isoform: “Structure of the human beta-myosin S2 fragment”. X-ray diffraction, 4 pockets (best druggability 0.41). MolNFT v1 #37320 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2FXO
Type: protein
Length: 508 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myosin heavy chain, cardiac muscle beta isoform
UniProt: P12883
Pockets: 4 · best druggability 0.41

Structure

x-ray diffraction · 4 distinct chains · 95% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myosin heavy chain, cardiac muscle beta isoform	protein	129	95% helix, 0% strand	P12883
B	Myosin heavy chain, cardiac muscle beta isoform	protein	125	93% helix, 0% strand	P12883
C	Myosin heavy chain, cardiac muscle beta isoform	protein	127	96% helix, 0% strand	P12883
D	Myosin heavy chain, cardiac muscle beta isoform	protein	127	95% helix, 0% strand	P12883

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	143	0.41	0.74	20	empty
2	126	0.36	0.72	18	empty
3	104	0.35	0.74	18	empty
4	105	0.34	0.73	23	empty

Interfaces

5 interfaces between chains.

A–B · 3549 Å² buried · 23 hydrogen bonds · protein-protein
C–D · 3539 Å² buried · 17 hydrogen bonds · protein-protein
B–D · 398 Å² buried · 5 hydrogen bonds · protein-protein
A–C · 312 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 78 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2FXO · Structure of the human beta-myosin S2 fragment · the same entry in another collection · chain D against D, TM-score 1.00
P12883 · AlphaFold monomer V2.0 prediction for myosin-7 (P12883) · a predicted model of the same protein · chain D against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12883
Elsewhere: RCSB PDB 2FXO · PDBe 2FXO · UniProt P12883

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.