MolNFT v1 · #37206 · protein
Crystal structure of the yeast kinetochore SPC24/SPC25 globular domain
2FTX · Hypothetical 25.2 kda protein in AFG3-SEB2 intergenic region: “Crystal structure of the yeast kinetochore SPC24/SPC25 globular domain”. X-ray diffraction, 2 ligands (NA, PO4), 1 pocket (best druggability 0.28). MolNFT v1 #37206 on…
- PDB
- 2FTX
- Type
- protein
- Length
- 149 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical 25.2 kda protein in AFG3-SEB2 intergenic region; Hypothetical 24.6 kda…
- UniProt
- P40014, Q04477
- Ligands
- NA, PO4
- Pockets
- 1 · best druggability 0.28
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypothetical 25.2 kda protein in AFG3-SEB2 intergenic region | protein | 90 | 42% helix, 22% strand | P40014 |
| B | Hypothetical 24.6 kda protein in ILV2-ADE17 intergenic region | protein | 59 | 44% helix, 20% strand | Q04477 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.28 | 0.74 | 10 | NA |
Interfaces
1 interface between chains.
- A–B · 1228 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (engineered).
Compared structures
- 2FTX · Crystal structure of the yeast kinetochore Spc24/Spc25 globular domain · the same entry in another collection · chain A against A, TM-score 1.00
- P40014 · AlphaFold monomer V2.0 prediction for kinetochore protein SPC25 (P40014) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q04477 · AlphaFold monomer V2.0 prediction for kinetochore protein SPC24 (Q04477) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40014
- Every structure of UniProt Q04477
- Elsewhere: RCSB PDB 2FTX · PDBe 2FTX · UniProt P40014 · UniProt Q04477
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