MolNFT v1 · #37168 · protein

Mitogen activated protein kinase P38ALPHA (D176A+F327S) activating mutant form-B

2FSM · Mitogen-activated protein kinase 14: “Mitogen activated protein kinase P38ALPHA (D176A+F327S) activating mutant form-B”. X-ray diffraction, 7 pockets (best druggability 0.64). MolNFT v1 #37168 on GenesisL1: 3D structure, binding…

PDB: 2FSM
Type: protein
Length: 326 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitogen-activated protein kinase 14
EC: 2.7.1.37
UniProt: Q16539
Pockets: 7 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	Mitogen-activated protein kinase 14 (EC 2.7.1.37)	protein	326	37% helix, 15% strand	Q16539

Ligands and binding sites

BOG · octyl beta-D-glucopyranoside · additive · chains X

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	224	0.64	0.82	29	BOG
2	185	0.57	0.80	22	empty
3	169	0.55	0.80	20	empty
4	131	0.45	0.77	18	empty
5	80	0.36	0.76	17	empty

Compared structures

2FSM · mitogen activated protein kinase p38alpha (D176A+F327S) activating mutant form-B · the same entry in another collection · chain X against X, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16539
Elsewhere: RCSB PDB 2FSM · PDBe 2FSM · UniProt Q16539

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