MolNFT v1 · #37163 · protein

Complex SECA:AMP-pnp from escherichia COLI

2FSH · Preprotein translocase seca subunit: “Complex SECA:AMP-pnp from escherichia COLI”. X-ray diffraction, 1 ligand (ANP), 20 pockets (best druggability 0.75). MolNFT v1 #37163 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 2FSH
Type: protein
Length: 1,413 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Preprotein translocase seca subunit
UniProt: P10408
Ligands: ANP
Pockets: 20 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 57% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Preprotein translocase seca subunit	protein	691	57% helix, 11% strand	P10408
B	Preprotein translocase seca subunit	protein	722	56% helix, 10% strand	P10408

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	575	0.75	0.82	79	ANP
2	284	0.68	0.84	49	empty
3	506	0.67	0.78	58	empty
4	181	0.63	0.84	33	empty
5	302	0.63	0.80	41	empty

Interfaces

1 interface between chains.

A–B · 1400 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

2FSH · Complex SecA:AMP-PNP from Escherichia coli · the same entry in another collection · chain A against A, TM-score 1.00
P10408 · AlphaFold monomer V2.0 prediction for protein translocase subunit seca (P10408) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10408
Elsewhere: RCSB PDB 2FSH · PDBe 2FSH · UniProt P10408

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