MolNFT v1 · #37161 · protein
Escherichia COLI seca, the preprotein translocase dimeric ATPase
2FSF · Preprotein translocase seca subunit: “Escherichia COLI seca, the preprotein translocase dimeric ATPase”. X-ray diffraction, 20 pockets (best druggability 0.71). MolNFT v1 #37161 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 2FSF
- Type
- protein
- Length
- 1,409 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Preprotein translocase seca subunit
- UniProt
- P10408
- Pockets
- 20 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 57% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Preprotein translocase seca subunit | protein | 686 | 58% helix, 11% strand | P10408 |
| B | Preprotein translocase seca subunit | protein | 723 | 56% helix, 10% strand | P10408 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 422 | 0.71 | 0.82 | 67 | empty |
| 2 | 288 | 0.68 | 0.84 | 49 | empty |
| 3 | 401 | 0.64 | 0.78 | 49 | empty |
| 4 | 209 | 0.64 | 0.83 | 25 | empty |
| 5 | 260 | 0.63 | 0.81 | 41 | empty |
Interfaces
1 interface between chains.
- A–B · 1496 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 2FSF · Escherichia coli SecA, the preprotein translocase dimeric ATPase · the same entry in another collection · chain A against A, TM-score 1.00
- P10408 · AlphaFold monomer V2.0 prediction for protein translocase subunit seca (P10408) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10408
- Elsewhere: RCSB PDB 2FSF · PDBe 2FSF · UniProt P10408
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