MolNFT v1 · #37137 · protein
Crystal structure of sara, a transcription regulator from staphylococcus aureus
2FRH · Staphylococcal accessory regulator a: “Crystal structure of sara, a transcription regulator from staphylococcus aureus”. X-ray diffraction, 1 ligand (CA), 2 pockets (best druggability 0.53). MolNFT v1 #37137 on GenesisL1: 3D…
- PDB
- 2FRH
- Type
- protein
- Length
- 254 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Staphylococcal accessory regulator a
- UniProt
- Q7A1N5
- Ligands
- CA
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 60% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Staphylococcal accessory regulator a | protein | 127 | 60% helix, 6% strand | Q7A1N5 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 184 | 0.53 | 0.78 | 27 | empty |
| 2 | 146 | 0.49 | 0.78 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1814 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2FRH · Crystal Structure of Sara, A Transcription Regulator From Staphylococcus Aureus · the same entry in another collection · chain B against B, TM-score 1.00
- Q7A1N5 · AlphaFold monomer V2.0 prediction for transcriptional regulator sara (Q7A1N5) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7A1N5
- Elsewhere: RCSB PDB 2FRH · PDBe 2FRH · UniProt Q7A1N5
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