MolNFT v1 · #36685 · protein
Crystal structure of fibroblast growth factor (FGF)8B in complex with FGF receptor (fgfr) 2C
2FDB · Fibroblast growth factor 8 isoform B: “Crystal structure of fibroblast growth factor (FGF)8B in complex with FGF receptor (fgfr) 2C”. X-ray diffraction, 6 pockets (best druggability 0.65). MolNFT v1 #36685 on GenesisL1: 3D…
- PDB
- 2FDB
- Type
- protein
- Length
- 685 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor 8 isoform B; Fibroblast growth factor receptor 2
- EC
- 2.7.1.112
- UniProt
- P55075, Q9UQH9
- Pockets
- 6 · best druggability 0.65
Structure
x-ray diffraction · 4 distinct chains · 10% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M | Fibroblast growth factor 8 isoform B | protein | 149 | 13% helix, 38% strand | P55075 |
| P | Fibroblast growth factor receptor 2 (EC 2.7.1.112) | protein | 197 | 8% helix, 55% strand | Q9UQH9 |
| N | Fibroblast growth factor 8 isoform B | protein | 148 | 13% helix, 38% strand | P55075 |
| R | Fibroblast growth factor receptor 2 (EC 2.7.1.112) | protein | 191 | 8% helix, 52% strand | Q9UQH9 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 603 | 0.65 | 0.76 | 63 | empty |
| 2 | 516 | 0.61 | 0.75 | 55 | empty |
| 3 | 234 | 0.55 | 0.78 | 28 | empty |
| 4 | 103 | 0.38 | 0.75 | 18 | empty |
| 5 | 76 | 0.33 | 0.75 | 13 | empty |
Interfaces
5 interfaces between chains.
- M–P · 1810 Ų buried · 31 hydrogen bonds · protein-protein
- N–R · 1689 Ų buried · 28 hydrogen bonds · protein-protein
- P–R · 988 Ų buried · 14 hydrogen bonds · protein-protein
- M–R · 152 Ų buried · 0 hydrogen bonds · protein-protein
- P–N · 147 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2FDB · Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR)… · the same entry in another collection · chain M against M, TM-score 1.00
- P55075 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 8 (P55075) · a predicted model of the same protein · chain M against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55075
- Every structure of UniProt Q9UQH9
- Elsewhere: RCSB PDB 2FDB · PDBe 2FDB · UniProt P55075 · UniProt Q9UQH9
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